Hemoglobin S
The interaction between Val 6 (left) on one chain of one hemoglobin molecule and a hydrophobic patch formed by Phe 85 (top right) and Leu 88 (bottom right) on a chain of another deoxygenated hemoglobin molecule leads to hemoglobin aggregation.
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PDB FILE:2HBS
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To view Hemoglobin S molecule using Chime 3D PDB FILE: 2HBS Harrington, D.J., Adachi, K., Royer Jr., W.E. (1997) The high resolution crystal structure of deoxyhemoglobin S. J.Mol.Biol. 272: 398-407
The Hydrophobic Pocket The interaction between Val 6 (yellow) on one chain of one hemoglobin molecule and a hydrophobic patch formed by Phe 85 (blue) and Leu 88 (gey) on a chain of another deoxygenated hemoglobin molecule leads to hemoglobin aggregation.
double click for backbone structure showing pocket
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