Laninamivir Molecule-- Anti-Viral Drug for Influenza

laninamivir Molecule Ball and Spacefill/CPK

The Laninamivir Molecule

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laninamivir Molecular Structure

Laninamivir Chemical Formula: C13H22N4O7

Four drugs have been approved to fight the Flu: Amantadine (Symmetrel)Oseltamivir (Tamiflu); Rimantadine (Flumadine) ; and Zanamivir (Relenza)

Laninamivir (CS-8958) is a neuraminidase inhibitor which is being researched for the treatment and prophylaxis of Influenzavirus A and Influenzavirus B.[1] It is currently in Phase III clinical trials.[2] It is a long-acting neuraminidase inhibitor administered by nasal inhalation.[3]

Laninamivir was approved for influenza treatment in Japan in 2010 and for prophylaxis in 2013. It is currently marketed under the name Inavir by Daiichi Sankyo. Biota Pharmaceuticals [4] and Daiichi Sankyo co-own Laninamivir. On 1 April 2011, BARDA awarded up to an estimated U$231m to Biota Pharmaceuticals (Formerly Biota Holdings Ltd) wholly owned subsidiary, Biota Scientific Management Pty Ltd, for the advanced development of Laninamivir in the US.[5] It is under clinical evaluations in other countries.[3]


  1.  Yamashita M, Tomozawa T, Kakuta M, Tokumitsu A, Nasu H, Kubo S (January 2009). "CS-8958, a prodrug of the new neuraminidase inhibitor R-125489, shows long-acting anti-influenza virus activity"Antimicrobial Agents and Chemotherapy53 (1): 186–92. doi:10.1128/AAC.00333-08.
  2. Hayden F (January 2009). "Developing new antiviral agents for influenza treatment: what does the future hold?". Clinical Infectious Diseases. 48. Suppl 1 (S1): S3–13. doi:10.1086/591851
  3. Samson, M; Pizzorno, A; Abed, Y; Boivin, G (May 2013). "Influenza virus resistance to neuraminidase inhibitors". Antiviral Research98 (2): 174–85. doi:10.1016/j.antiviral.2013.03.014

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